Symbol
Name
ID

Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI:97312

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased circulating antibody level	Autoimmune hemolytic anemia	Recurrent sinusitis	Subacute progressive viral hepatitis	Recurrent skin infections	Recurrent pneumonia	Combined immunodeficiency	Recurrent infections	Recurrent sinopulmonary infections
Disease(s) Associated with NFKB1	Decreased circulating antibody level	Autoimmune hemolytic anemia	Recurrent sinusitis	Subacute progressive viral hepatitis	Recurrent skin infections	Recurrent pneumonia	Combined immunodeficiency	Recurrent infections	Recurrent sinopulmonary infections
common variable immunodeficiency 12
hepatocellular carcinoma

Mouse Phenotypes

immune system phenotype

decreased B cell proliferation

increased B cell proliferation

decreased T cell proliferation

increased susceptibility to induced colitis

large intestinal inflammation

cecum inflammation

peritoneal inflammation

enlarged spleen

abnormal class switch recombination

myeloid hyperplasia

decreased myeloid dendritic cell number

decreased B-1 B cell number

decreased B-1a cell number

decreased marginal zone B cell number

decreased NK cell number

decreased central memory CD4-positive, alpha-beta T cell number

decreased effector memory CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased NK T cell number

decreased memory T cell number

decreased regulatory T cell number

decreased single-positive T cell number

decreased osteoclast cell number

increased leukocyte cell number

abnormal lymphocyte physiology

abnormal B cell physiology

decreased IgA level

decreased IgE level

increased IgE level

decreased IgG1 level

increased IgG1 level

decreased IgG3 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

increased immunoglobulin level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal macrophage physiology

decreased circulating interleukin-2 level

abnormal Peyer's patch follicle morphology

abnormal Peyer's patch T cell area morphology

abnormal Peyer's patch germinal center morphology

decreased Peyer's patch number

small Peyer's patches

enlarged lymph nodes

abnormal inguinal lymph node morphology

absent inguinal lymph nodes

small inguinal lymph nodes

abnormal lymph organ size

lymphoid hyperplasia

abnormal professional antigen presenting cell physiology

abnormal dendritic cell physiology

abnormal humoral immune response

impaired humoral immune response

abnormal cytokine secretion

decreased interleukin-1 beta secretion

decreased interleukin-2 secretion

decreased interleukin-4 secretion

decreased interleukin-6 secretion

decreased tumor necrosis factor secretion

decreased susceptibility to autoimmune diabetes

abnormal inflammatory response

liver inflammation

lung inflammation

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

decreased susceptibility to Picornaviridae infection induced morbidity/mortality

Availability

Mouse Genotype

Nfkb1^M1Btlr/Nfkb1^M1Btlr

Nfkb1^m2Btlr/Nfkb1^m2Btlr

Nfkb1^M3Btlr/Nfkb1^M3Btlr

Nfkb1^M4Btlr/Nfkb1^M4Btlr

Nfkb1^M5Btlr/Nfkb1^M5Btlr

Nfkb1^M6Btlr/Nfkb1^M6Btlr

Nfkb1^{tm1a(KOMP)Wtsi}/Nfkb1^{tm1a(KOMP)Wtsi}

Nfkb1^tm1Bal/Nfkb1^tm1Bal

Nfkb1^tm1Brv/Nfkb1^tm1Brv

Nfkb1^tm1Sley/Nfkb1^tm1Sley

Nfkb1^M1Btlr/Nfkb1⁺

Nfkb1^m2Btlr/Nfkb1⁺

Nfkb1^M3Btlr/Nfkb1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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